A PP4-Phosphatase Complex Dephosphorylates γ-H2AX Generated during DNA Replication
نویسندگان
چکیده
منابع مشابه
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.
The histone H2A variant H2AX is rapidly phosphorylated in response to DNA double-stranded breaks to produce gamma-H2AX. gamma-H2AX stabilizes cell-cycle checkpoint proteins and DNA repair factors at the break site. We previously found that the protein phosphatase PP2A is required to resolve gamma-H2AX foci and complete DNA repair after exogenous DNA damage. Here we describe a three-protein PP4 ...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2008
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2008.05.016